Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023741 | 0.84 | TSHR (0.72) | TSHRPLK1CA9CA12HTT | |
| SCHEMBL9024013 | 0.81 | TSHR (0.54) | TSHRPLK1CA9CA12HTT | |
| SCHEMBL8548403 | 0.79 | CA12 (0.43) | TSHRPLK1CA9CA12HTT | |
| SCHEMBL2546794 | 0.78 | KHK (0.58) | CA9CHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL1501466 | 0.77 | TSHR (0.59) | TSHRPLK1CA9CA12HTT | |
| Hydrochloric Acid SCHEMBL2543458 | 0.76 | KHK (0.57) | CA9CHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL24733697 | 0.75 | CYP1A2 (0.57) | TSHRCA9CA12HTTMAPT | |
| SCHEMBL3699843 | 0.75 | ELANE (0.41) | MAPTCHEK1AURKACSNK1A1CDK8 | |
| SCHEMBL1501649 | 0.74 | TSHR (0.59) | TSHRPLK1CA9CA12HTT | |
| SCHEMBL9024249 | 0.68 | ALDH1A1 (0.57) | TSHRCA9CA12HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |