Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.38 |
| ▸ | NQO1 | P15559 | 5/20 | 0.35 |
| ▸ | NQO2 | P16083 | 5/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024054 | 0.90 | TOP2A (0.38) | TOP2ANQO2CHRM2GLAHPGD | |
| SCHEMBL9024575 | 0.85 | NQO2 (0.36) | NQO1NQO2GLAHPGDAPEX1 | |
| SCHEMBL9023847 | 0.84 | G6PD (0.39) | NQO1NQO2GLAHPGDAPEX1 | |
| SCHEMBL9024703 | 0.83 | NQO2 (0.48) | NQO1NQO2 | |
| SCHEMBL9025537 | 0.82 | TOP2A (0.36) | TOP2ACHRM2HASPINDYRK2 | |
| SCHEMBL9025183 | 0.82 | NQO2 (0.38) | TOP2ANQO1NQO2HASPINDYRK2 | |
| SCHEMBL9024240 | 0.82 | KDM1A (0.38) | NQO1NQO2KDM1AL3MBTL1KCNA3 | |
| SCHEMBL9024051 | 0.81 | CD274 (0.41) | L3MBTL1 | |
| SCHEMBL8546736 | 0.81 | NQO2 (0.43) | TOP2ANQO1NQO2 | |
| SCHEMBL9025524 | 0.80 | TOP2A (0.38) | TOP2ANQO1NQO2CHRM2HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |