Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | STING1 | Q86WV6 | 4/20 | 0.37 |
| ▸ | IRF3 | Q14653 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024234 | 0.83 | BRD4 (0.44) | BRD4LMNASMN1; SMN2HTT | |
| SCHEMBL9023722 | 0.81 | TOP2A (0.38) | L3MBTL1 | |
| SCHEMBL9024984 | 0.75 | NQO2 (0.45) | — | |
| SCHEMBL9024240 | 0.74 | KDM1A (0.38) | KMT2AL3MBTL1MEN1 | |
| SCHEMBL9023946 | 0.74 | NQO2 (0.42) | — | |
| SCHEMBL9023829 | 0.74 | NQO2 (0.43) | — | |
| SCHEMBL9024129 | 0.70 | ABCB1 (0.36) | KMT2AL3MBTL1MEN1SMN1; SMN2GAA | |
| SCHEMBL4366616 | 0.69 | CD274 (0.58) | CD274KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL9025389 | 0.69 | KDM1A (0.41) | KMT2AL3MBTL1MEN1LMNASMN1; SMN2 | |
| SCHEMBL9024667 | 0.69 | NQO1 (0.39) | CD274KMT2AMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |