Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901499 | 0.78 | DGAT1 (0.61) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL901617 | 0.78 | DGAT1 (0.50) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL900018 | 0.77 | DGAT1 (0.55) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10188922 | 0.73 | DGAT1 (0.41) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL6528644 | 0.71 | KDM4E (0.56) | ADORA2ACDK9HPSEPDE4APDE4B | |
| SCHEMBL902399 | 0.71 | DGAT1 (0.60) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL10189190 | 0.70 | DGAT1 (0.44) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902749 | 0.69 | DGAT1 (0.55) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL28027631 | 0.69 | TNKS (0.54) | CDK9HPSE | |
| SCHEMBL900619 | 0.68 | DGAT1 (0.56) | DGAT1SOAT1FAAHCHRM2DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |