Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 9/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023822 | 0.87 | HTR2A (0.39) | HTR7GABRA5DRD2HTR2AHTR2C | |
| SCHEMBL9445150 | 0.87 | HTR7 (0.41) | HTR7GABRA5DRD2HTR2AHTR1A | |
| SCHEMBL9024797 | 0.87 | HTR7 (0.36) | HTR7DRD2HTR2AHTR1A | |
| SCHEMBL9445148 | 0.81 | HTR2A (0.40) | HTR7GABRA5HTR2AHTR2CCYP1A2 | |
| SCHEMBL9023458 | 0.81 | SMN1; SMN2 (0.33) | HTR7DRD2HTR2AHTR1AGRM5 | |
| SCHEMBL9023952 | 0.81 | HTR7 (0.41) | HTR7GABRA5DRD2HTR2AHTR2C | |
| SCHEMBL9689077 | 0.81 | DRD2 (0.43) | DRD2HTR2AHTR1AHTR2C | |
| SCHEMBL9025050 | 0.78 | HTR2C (0.53) | DRD2HTR2AHTR2CCYP1A2CYP3A4 | |
| SCHEMBL9445139 | 0.78 | HDAC1 (0.41) | HTR7DRD2HTR2AHTR1AGRM5 | |
| Hydrochloric Acid SCHEMBL9024955 | 0.78 | HTR2C (0.52) | DRD2HTR2AHTR2CCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474012-B1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5256672-A | Antipsychotic, analgesic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-26 | — | — | US | disclosed |
| US-5180834-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-19 | — | — | US | disclosed |
| US-5114936-A | Antipsychotic and analgesic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0474012-A1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-03-11 | — | — | EP | disclosed |