Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | HMGCR | P04035 | 4/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024104 | 0.86 | PKM (0.39) | PKMHMGCRGPR183ALDH1A1KDM4E | |
| SCHEMBL9024101 | 0.86 | PKM (0.39) | PKMHMGCRGPR183ALDH1A1KDM4E | |
| SCHEMBL9732188 | 0.80 | PKM (0.37) | PKMGPR183ALDH1A1KDM4EMAPT | |
| SCHEMBL9025069 | 0.77 | HMGCR (0.57) | HMGCRALDH1A1 | |
| SCHEMBL9025064 | 0.77 | HMGCR (0.57) | HMGCRALDH1A1 | |
| SCHEMBL9518155 | 0.75 | HMGCR (0.53) | HMGCRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9024612 | 0.74 | HMGCR (0.43) | PKMHMGCRGPR183KMT2A | |
| SCHEMBL9024600 | 0.74 | HMGCR (0.43) | PKMHMGCRGPR183KMT2A | |
| SCHEMBL9518598 | 0.69 | HMGCR (0.56) | HMGCR | |
| SCHEMBL9024748 | 0.68 | ELAVL1 (0.45) | PKMHMGCRSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464845-B1 | Pyrrole derivatives | SHIONOGI & CO (JP) | 1996-06-05 | — | — | EP | disclosed |
| US-5128366-A | Enzyme inhibitors, anticholesterol | SHINOGI & CO., LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| EP-0464845-A1 | Pyrrole derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1992-01-08 | — | — | EP | disclosed |