Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 7/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518437 | 0.82 | HMGCR (0.56) | HMGCRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9750945 | 0.82 | HMGCR (0.56) | HMGCRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9751046 | 0.81 | HMGCR (0.55) | HMGCRALDH1A1MAPK13MAPK12MAPK11 | |
| SCHEMBL9518598 | 0.80 | HMGCR (0.56) | HMGCRTGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL9024469 | 0.75 | PKM (0.38) | HMGCRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9750874 | 0.73 | HMGCR (0.41) | HMGCRTGFBR1KDM4EALDH1A1GAA | |
| SCHEMBL9024739 | 0.72 | NR4A2 (0.34) | NR3C1PGRNR3C2KDM4EALDH1A1 | |
| SCHEMBL9518177 | 0.71 | HMGCR (0.47) | HMGCR | |
| SCHEMBL9764350 | 0.71 | KDM4E (0.43) | HMGCRKDM4EALDH1A1 | |
| SCHEMBL9518302 | 0.70 | HMGCR (0.66) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |
| EP-0300249-A1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |