Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023702 | 0.84 | HTR7 (0.57) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL9024252 | 0.83 | HTR7 (0.56) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL6169077 | 0.82 | HTR1A (0.44) | DRD2HTR2AHTR1AADRA1AADRA1B | |
| SCHEMBL9371795 | 0.82 | DRD2 (0.64) | DRD2KCNH2HTR2AHTR1A | |
| SCHEMBL31013504 | 0.81 | HTR1A (0.71) | DRD2HTR2AHTR1AADRA1AADRA1B | |
| SCHEMBL9370364 | 0.81 | HTR1A (0.71) | DRD2HTR2AHTR1AADRA1AADRA1B | |
| SCHEMBL9029235 | 0.81 | ADRB2 (0.49) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL9372589 | 0.81 | HTR1A (0.69) | DRD2HTR2AHTR1AADRA1AADRA1B | |
| SCHEMBL9372762 | 0.81 | DRD3 (0.61) | DRD2HTR2AHTR1AADRA1AADRA1B | |
| SCHEMBL7472750 | 0.80 | DRD4 (0.42) | DRD2HTR1AADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0463810-B1 | Heterocyclic compound and psychopharmaceutical composition containing same | SUNTORY LTD (JP) | 1996-01-10 | — | — | EP | disclosed |
| US-5158947-A | CONDENSED HETEROCYCLIC COMPOUNDS AND PSYCHOPHARMACEUTICAL COMPOSITION CONTAINING SAME | SUNTORY LIMITED (JP) | 1992-10-27 | — | — | US | disclosed |
| EP-0463810-A1 | Heterocyclic compound and psychopharmaceutical composition containing same | SUNTORY LIMITED (JP) | 1992-01-02 | — | — | EP | disclosed |