Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP9 | P55211 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026411 | 0.89 | ALDH1A1 (0.43) | TSHRGAAKMT2AHPGDMEN1 | |
| SCHEMBL9026841 | 0.88 | SHMT2 (0.37) | TSHRKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL9026134 | 0.88 | RRM1 (0.33) | TSHRGAAKMT2AHPGDMEN1 | |
| SCHEMBL9024884 | 0.88 | KDM4E (0.32) | TSHRGAAKMT2AALDH1A1KDM4E | |
| SCHEMBL9026086 | 0.85 | ALDH1A1 (0.37) | TSHRKMT2AHPGDMEN1ALDH1A1 | |
| SCHEMBL9025844 | 0.85 | ACLY (0.35) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9026448 | 0.83 | KMT2A (0.39) | TSHRKMT2AMEN1ALDH1A1KDM4E | |
| Water SCHEMBL9026100 | 0.83 | MAPT (0.33) | TSHRKMT2AHPGDMEN1ALDH1A1 | |
| SCHEMBL9031677 | 0.83 | KMT2A (0.36) | TSHRGAAKMT2AHPGDMEN1 | |
| SCHEMBL9026248 | 0.83 | TSHR (0.39) | TSHRKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |