Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025844 | 0.92 | ACLY (0.35) | SHMT2MAPK1METAP2KMT2AMEN1 | |
| SCHEMBL9026248 | 0.90 | TSHR (0.39) | KMT2AMEN1NPC1SLC9A1TSHR | |
| SCHEMBL9026385 | 0.90 | CRHR1 (0.35) | SHMT2METAP2KMT2AMEN1NPC1 | |
| SCHEMBL9026534 | 0.90 | SLC9A1 (0.35) | SHMT2KMT2AMEN1NPC1POLB | |
| SCHEMBL9026425 | 0.89 | TSHR (0.35) | MAPK1HTTKMT2AMEN1POLB | |
| SCHEMBL9025652 | 0.88 | TSHR (0.41) | HTTKMT2AMEN1POLBTSHR | |
| SCHEMBL9026411 | 0.88 | ALDH1A1 (0.43) | MAPK1METAP2HTTKMT2AMEN1 | |
| SCHEMBL9024884 | 0.87 | KDM4E (0.32) | KMT2ASLC9A1TSHRALDH1A1PKM | |
| SCHEMBL9026134 | 0.87 | RRM1 (0.33) | MAPK1HTTKMT2AMEN1NPC1 | |
| SCHEMBL9026856 | 0.86 | SHMT2 (0.35) | SHMT2MAPK1HTTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |