Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALB | P02768 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | TK1 | P04183 | 3/20 | 0.44 |
| ▸ | TYMP | P19971 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024558 | 1.00 | LMNA (0.52) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL9309840 | 0.90 | LMNA (0.58) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL10757124 | 0.88 | ALDH1A1 (0.49) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL9025564 | 0.83 | TK1 (0.50) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL9025572 | 0.83 | TK1 (0.50) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL10746824 | 0.80 | ALDH1A1 (0.52) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL9025283 | 0.79 | TK2 (0.45) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL9025397 | 0.79 | TK2 (0.56) | BLMTK1PMP22 | |
| SCHEMBL9025814 | 0.77 | TK2 (0.41) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL9864109 | 0.76 | TK2 (0.38) | LMNAALBBLMALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458363-B1 | Fluorinated bis(hydroxymethyl) cyclobutyl purines and pyrimidines | SQUIBB & SONS INC (US) | 1996-02-07 | — | — | EP | disclosed |
| WO-1991018969-A1 | FLUORINATED BIS(HYDROXYMETHYL)CYCLOBUTYL PURINES AND PYRIMIDINES | E.R. SQUIBB & SONS, INC. (US) | 1991-12-12 | — | — | WO | disclosed |