Sugi Predict

Sugi Predict / Compounds / SCHEMBL902629

SCHEMBL902629

SCHEMBL902629

COCCc1nc2ccnn2c(O)c1Cc1ccc(Cl)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ APLNR P35414 1/20 0.35
▸ KCNN3 Q9UGI6 1/20 0.34
▸ PDE10A Q9Y233 1/20 0.34
▸ ENPP1 P22413 1/20 0.34
▸ LMNA P02545 3/20 0.33
▸ TP53 P04637 1/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ MKNK1 Q9BUB5 1/20 0.33
▸ PRKAB2 O43741 1/20 0.33
▸ PRKAG1 P54619 1/20 0.33
▸ PRKAA2 P54646 1/20 0.33
▸ PRKAA1 Q13131 1/20 0.33
▸ PRKAG3 Q9UGI9 1/20 0.33
▸ PRKAG2 Q9UGJ0 1/20 0.33
▸ PRKAB1 Q9Y478 1/20 0.33
▸ ALOX5 P09917 1/20 0.33
▸ ENPP2 Q13822 1/20 0.33
▸ PKM P14618 1/20 0.33
▸ KDM4E B2RXH2 2/20 0.32
▸ CYP1A2 P05177 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL902390 0.89 PDE10A (0.35) KCNN3PDE10AENPP1LMNAALDH1A1
SCHEMBL902589 0.87 PDE10A (0.38) KCNN3PDE10AENPP1LMNAALDH1A1
SCHEMBL15261556 0.85 PRKAB2 (0.37) KCNN3PDE10AENPP1LMNATP53
SCHEMBL15274696 0.81 ALDH1A1 (0.36) PDE10AENPP1LMNATP53ALDH1A1
SCHEMBL902316 0.80 ENPP2 (0.47) KCNN3PDE10AENPP1LMNATP53
SCHEMBL902441 0.79 MAPT (0.42) TP53ALDH1A1KDM4EHPGDHTT
SCHEMBL902910 0.79 NPC1 (0.40) KCNN3LMNAENPP2KDM4ENPC1
SCHEMBL902369 0.78 PDE4B (0.40) LMNAALDH1A1PDE4APDE4BPDE4C
SCHEMBL902279 0.78 MAPK1 (0.37) PDE10AENPP1LMNAALDH1A1ENPP2
SCHEMBL902398 0.77 PRKAB2 (0.34) KCNN3PDE10ALMNAALDH1A1PRKAB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LIMITED (GB) 2013-09-26 — — US disclosed
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LIMITED (GB) 2013-09-26 — — US disclosed
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LIMITED (GB) 2013-09-26 — — US disclosed
EP-2621928-A1 7-HYDROXY-PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS Proximagen Limited (GB) 2013-08-07 — — EP disclosed
WO-2012041817-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LTD (GB) 2012-04-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS CCR2, CCR5, CCR1 APLNR 465/4885KCNN3 4658/4885PDE10A 1877/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.