Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597489 | 0.79 | CCNK (0.31) | MAPTALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL2389319 | 0.74 | ALDH1A1 (0.37) | ALDH1A1CYP3A4TDP1L3MBTL1 | |
| SCHEMBL1095862 | 0.74 | CYP1A2 (0.41) | ALDH1A1KMT2ACYP1A2POLBCYP3A4 | |
| SCHEMBL29556375 | 0.74 | POLB (0.42) | MAPTALDH1A1NPC1RAB9APOLB | |
| SCHEMBL22445327 | 0.71 | CNR2 (0.32) | — | |
| SCHEMBL12597099 | 0.71 | MAPK1 (0.54) | MAPTALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL2390425 | 0.70 | CTSK (0.34) | ALDH1A1L3MBTL1 | |
| SCHEMBL6078178 | 0.69 | HSD11B1 (0.38) | HSD11B1MAPTL3MBTL1LMNATLR8 | |
| SCHEMBL11680871 | 0.68 | SIGMAR1 (0.48) | HSD11B1HPGDSIGMAR1SMN1; SMN2 | |
| SCHEMBL8378237 | 0.68 | SIGMAR1 (0.48) | HSD11B1HPGDSIGMAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725783-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011905-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-05-04 | — | — | WO | disclosed |