Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.60 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755668 | 0.84 | KARS1 (0.60) | KARS1MAPT | |
| SCHEMBL902190 | 0.83 | KARS1 (0.58) | KARS1MAPTMAPK1 | |
| SCHEMBL902707 | 0.82 | SYK (0.76) | KARS1SYKMAP4K4 | |
| SCHEMBL1755667 | 0.79 | KARS1 (0.72) | KARS1MAPTMAPK1 | |
| SCHEMBL1704457 | 0.77 | ITK (0.55) | KARS1SYKMAPT | |
| SCHEMBL902808 | 0.76 | SYK (0.43) | KARS1SYKMAP4K4MINK1TNIK | |
| SCHEMBL902600 | 0.76 | KARS1 (1.00) | KARS1 | |
| SCHEMBL1704214 | 0.76 | KARS1 (0.77) | KARS1 | |
| SCHEMBL902681 | 0.75 | KARS1 (0.70) | KARS1 | |
| SCHEMBL1704879 | 0.75 | KARS1 (0.68) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |