Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9356958 | 0.79 | NR1I2 (0.40) | KIF11HTR2AHTR2CNEK1SIGMAR1 | |
| SCHEMBL9028624 | 0.78 | TLR7 (0.42) | HTR2AKCNH2 | |
| SCHEMBL8790299 | 0.76 | CCNB2 (0.41) | ESR1ESR2HTR2CNR1I2 | |
| SCHEMBL8790260 | 0.75 | ESR1 (0.39) | ESR1ESR2KIF11NR1I2 | |
| SCHEMBL8789330 | 0.74 | CCNB2 (0.40) | ESR1HTR2CNR1I2 | |
| SCHEMBL9028366 | 0.74 | CCNB2 (0.38) | KIF11NR1I2 | |
| SCHEMBL7692326 | 0.74 | ESR1 (0.43) | ESR1ESR2HTR2CNR1I2 | |
| SCHEMBL8792445 | 0.74 | CCNB2 (0.38) | ESR1KIF11HTR2CNR1I2 | |
| SCHEMBL9027686 | 0.74 | ALDH1A1 (0.39) | NR1I2 | |
| SCHEMBL9027574 | 0.73 | DRD2 (0.39) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736008-A1 | INDOLE DERIVATIVES AS ANTI-ESTROGENS | KARO BIO AB (SE) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017383-A1 | INDOLE DERIVATIVES AS ANTI-ESTROGENS | KARO BIO AB (SE) | 1995-06-29 | — | — | WO | disclosed |