Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
| ▸ | GSR | P00390 | 1/20 | 0.30 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6764099 | 0.84 | CA1 (0.36) | CA1CA2ALDH1A1MAPTKDM4E | |
| SCHEMBL6767062 | 0.81 | CA1 (0.33) | CA1CA2ALDH1A1MAPTKDM4E | |
| SCHEMBL6130778 | 0.80 | ALDH1A1 (0.38) | CA1CA2ALDH1A1MAPTKDM4E | |
| SCHEMBL9028993 | 0.75 | ALDH1A1 (0.35) | ALDH1A1MAPTKDM4E | |
| SCHEMBL6769049 | 0.75 | SMN1; SMN2 (0.39) | CA1CA2ALDH1A1MAPTKDM4E | |
| SCHEMBL4473157 | 0.74 | FDPS (0.34) | CA1CA2ALDH1A1MAPTKDM4E | |
| SCHEMBL5268555 | 0.74 | MEN1 (0.41) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL9028190 | 0.73 | MAOA (0.36) | ALDH1A1MAPTKDM4E | |
| SCHEMBL8633979 | 0.71 | ALDH1A1 (0.34) | ALDH1A1MAPTKDM4E | |
| SCHEMBL6768799 | 0.69 | SMN1; SMN2 (0.34) | CA1CA2ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |