Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.30 |
| ▸ | CNR1 | P21554 | 2/20 | 0.30 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.30 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6130778 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL9028997 | 0.77 | LDHA (0.35) | MAOAALDH1A1KDM4EMAPTGAA | |
| SCHEMBL10460200 | 0.73 | MAOA (0.37) | MAOAALDH1A1KDM4EMAPTGAA | |
| SCHEMBL9028187 | 0.73 | CA1 (0.36) | ALDH1A1KDM4EMAPT | |
| SCHEMBL6769049 | 0.73 | SMN1; SMN2 (0.39) | ALDH1A1KDM4EMAPTHIF1ARAB9A | |
| SCHEMBL9029066 | 0.72 | MAOB (0.45) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL8633979 | 0.69 | ALDH1A1 (0.34) | ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5537657 | 0.66 | MAPT (0.42) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL3592511 | 0.65 | ALDH1A1 (0.32) | ALDH1A1KDM4EMAPT | |
| SCHEMBL658523 | 0.65 | ALDH1A1 (0.32) | ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |