Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | XIAP | P98170 | 1/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSH | P09668 | 1/20 | 0.48 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3505882 | 1.00 | ALDH1A1 (0.52) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL5617244 | 1.00 | ALDH1A1 (0.52) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL962571 | 0.92 | TSHR (0.47) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL8716757 | 0.89 | MMP12 (0.56) | PTGS1TSHRLMNASRR | |
| SCHEMBL9134238 | 0.89 | SLC7A5 (0.49) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL31553563 | 0.86 | ALDH1A1 (0.53) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL1838248 | 0.86 | SLC6A2 (0.54) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL6826673 | 0.86 | TSHR (0.53) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL7701055 | 0.85 | LMNA (0.50) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL6902916 | 0.84 | TSHR (0.44) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580467-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | E. R. SQUIBB & SONS, L.L.C. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160060294-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | E. R. SQUIBB & SONS, L.L.C. | 2016-03-03 | — | — | US | disclosed |
| US-9226974-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | E. R. SQUIBB & SONS, L.L.C. (US) | 2016-01-05 | — | — | US | disclosed |
| US-20140323690-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | E. R. SQUIBB & SONS, L.L.C. | 2014-10-30 | — | — | US | disclosed |
| US-8802632-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, L.L.C. (US) | 2014-08-12 | — | — | US | disclosed |
| US-8772542-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, L.L.C. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130197259-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-20130189256-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| EP-0729456-A1 | NOVEL PROCESS FOR PREPARING (S)-1-[2(S)-(1,3-DIHYDRO-1,3-DIOXO-ISOINDOL-2-YL)-1-OXO-3-PHENYLPROPYL]-1,2,3,4-TETRAHYDRO-2-PYRIDINE-CARBOXYLIC ACID METHYL ESTER AND INTERMEDIATES THEREOF | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014663-A2 | NOVEL PROCESS FOR PREPARING (S)-1-[2(S)-(1,3-DIHYDRO-1,3-DIOXO-ISOINDO-2-YL)-1-OXO-3-PHENYLPROPYL]-1,2,3,4-TETRAHYDRO-2-PYRIDINE-CARBOXYLIC ACID METHYL ESTER AND INTERMEDIATES THEREOF | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060294-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ALDH1A1 1030/4885ALPI 4062/4885PKM 4639/4885 |
| US-20130189256-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ALDH1A1 1030/4885ALPI 4062/4885PKM 4639/4885 |
| US-20140323690-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ALDH1A1 1030/4885ALPI 4062/4885PKM 4639/4885 |
| US-20130197259-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ALDH1A1 1030/4885ALPI 4062/4885PKM 4639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.