Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | HMGCR | P04035 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 3/20 | 0.31 |
| ▸ | PPARA | Q07869 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028753 | 0.80 | ALOX5 (0.47) | ALOX5HMGCRKDM4EMAPTHSD17B10 | |
| SCHEMBL4015738 | 0.72 | ALOX5 (0.42) | ALOX5KDM4EHSD17B10PTPN1PTPN11 | |
| SCHEMBL17612610 | 0.72 | KDM4E (0.43) | ALOX5HMGCRKDM4EPTPN1PTPN11 | |
| SCHEMBL13924206 | 0.71 | ALOX5 (0.41) | ALOX5KDM4EMAPTTP53GAA | |
| SCHEMBL9027495 | 0.71 | PTPN1 (0.50) | ALOX5HMGCRKDM4EMAPTTP53 | |
| SCHEMBL9028266 | 0.70 | KDM4E (0.36) | ALOX5KDM4EMAPTGAAHTT | |
| SCHEMBL9029445 | 0.69 | ALOX5 (0.60) | ALOX5KDM4EMAPTTP53GAA | |
| SCHEMBL7734483 | 0.68 | ALOX5 (0.32) | ALOX5KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL27222273 | 0.68 | KDM4E (0.39) | ALOX5KDM4EMAPTTP53GAA | |
| SCHEMBL9028770 | 0.68 | RXRA (0.35) | KDM4EMAPTTP53GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |