Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 3/20 | 0.46 |
| ▸ | XDH | P47989 | 2/20 | 0.44 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028982 | 0.87 | XDH (0.49) | TYRXDHRNASEH1TRPA1PTGS1 | |
| SCHEMBL4301530 | 0.81 | GABRA1 (0.40) | TYRXDHRNASEH1GABRA1GABRB2 | |
| SCHEMBL9816379 | 0.80 | GABRA1 (0.59) | TYRXDHRNASEH1TRPA1PTGS1 | |
| SCHEMBL4163804 | 0.80 | RNASEH1 (0.49) | TYRRNASEH1TRPA1PTGS1CACNA1C | |
| SCHEMBL4303199 | 0.79 | XDH (0.37) | TYRXDHRNASEH1TRPA1PTGS1 | |
| SCHEMBL4174582 | 0.79 | RNASEH1 (0.47) | TYRRNASEH1TRPA1PTGS1CACNA1C | |
| SCHEMBL13914289 | 0.78 | RNASEH1 (0.46) | TYRRNASEH1TRPA1PTGS1CACNA1C | |
| SCHEMBL4160996 | 0.76 | RNASEH1 (0.45) | TYRRNASEH1TRPA1PTGS1CACNA1C | |
| SCHEMBL873331 | 0.75 | LMNA (0.42) | TYRXDHTRPA1PTGS1CACNA1C | |
| Beta-Thujaplicinol SCHEMBL524720 | 0.74 | RNASEH1 (0.62) | TYRRNASEH1TRPA1PTGS1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090081134-A1 | Oral Care Compositions Comprising Tropolone Compounds and Essential Oils and Methods of Using The Same | PAN PAULINE | 2009-03-26 | — | — | US | disclosed |
| US-6924398-B2 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | WARNER-LAMBERT COMPANY LLC (US) | 2005-08-02 | — | — | US | disclosed |
| EP-1536759-A1 | ORAL CARE COMPOSITION COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS | Warner-Lambert Company LLC (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040204501-A1 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | CHENANGO ZERO LLC | 2004-10-14 | — | — | US | disclosed |
| US-20040185010-A1 | Oral care compositions comprising tropolone compounds and essential oils and methods of using the same | MCNEIL-PPC, INC | 2004-09-23 | — | — | US | disclosed |
| US-6787675-B2 | CHEMICAL STABILITY; SOLUBILITY; KILLING PATHOGENIC MICROORGANISMS RESPONSIBLE FOR ODOR, PLAQUE AND GINGIVITIS; MOUTHWASHES, RINSES | WARNER-LAMBERT COMPANY | 2004-09-07 | — | — | US | disclosed |
| WO-2004012692-A1 | ORAL CARE COMPOSITION COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-12 | — | — | WO | disclosed |
| US-6689342-B1 | DENTISTRY | WARNER-LAMBERT COMPANY | 2004-02-10 | — | — | US | disclosed |
| US-20040018154-A1 | ORAL CARE COMPOSITIONS COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS AND METHODS OF USING THE SAME | MCNEIL-PPC, INC | 2004-01-29 | — | — | US | disclosed |
| US-20040018216-A1 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | JOHNSON & JOHNSON CONSUMER INC. | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090081134-A1 | Oral Care Compositions Comprising Tropolone Compounds and Essential Oils and Methods of Using The Same | TMSB10, PIGS, TPM3 | TYR 55/4885XDH 1078/4885RNASEH1 2853/4885 |
| US-20040185010-A1 | Oral care compositions comprising tropolone compounds and essential oils and methods of using the same | TMSB10, PIGS, TPM3 | TYR 55/4885XDH 1078/4885RNASEH1 2853/4885 |
| US-20040018216-A1 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | TPM3, TPM4, TMSB10 | TYR 185/4885XDH 625/4885RNASEH1 3266/4885 |
| US-20040204501-A1 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | TPM3, TPM4, TMSB10 | TYR 185/4885XDH 625/4885RNASEH1 3266/4885 |
| US-20040018154-A1 | ORAL CARE COMPOSITIONS COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS AND METHODS OF USING THE SAME | TMSB10, PIGS, TPM3 | TYR 55/4885XDH 1078/4885RNASEH1 2853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.