Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972522 | 0.89 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL9027127 | 0.84 | MAPT (0.41) | RAB9ASMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9080811 | 0.81 | ALDH1A1 (0.42) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL6972709 | 0.81 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL6968612 | 0.80 | ROCK2 (0.47) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL6972421 | 0.79 | POLB (0.54) | NPC1RAB9ASMN1; SMN2MAPTROCK2 | |
| SCHEMBL9023637 | 0.79 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL9033928 | 0.79 | SMN1; SMN2 (0.38) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7103005 | 0.78 | MGLL (0.44) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL7097234 | 0.77 | PARP1 (0.41) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0729459-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014007-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |