Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966124 | 0.92 | ROCK2 (0.47) | ROCK2NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6972522 | 0.88 | NPC1 (0.53) | ROCK2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6970271 | 0.86 | HRH4 (0.44) | LMNAPOLBCYP2C9CYP2C19HRH4 | |
| SCHEMBL6965330 | 0.84 | ESR1 (0.42) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL6974399 | 0.84 | ESR1 (0.42) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL6972584 | 0.84 | L3MBTL1 (0.43) | SMN1; SMN2L3MBTL1LMNAPOLBMAPT | |
| SCHEMBL7973065 | 0.83 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1RECQL | |
| SCHEMBL6972709 | 0.83 | NPC1 (0.52) | ROCK2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9029314 | 0.80 | NPC1 (0.52) | ROCK2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6970199 | 0.79 | RAB9A (0.40) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0729459-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014007-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |