Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 4/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9030241 | 0.78 | P2RX4 (0.37) | ALDH1A1LMNADHFRSMN1; SMN2GSK3A | |
| SCHEMBL3218987 | 0.67 | HPGD (0.48) | ALDH1A1LMNAALDH1A3SMN1; SMN2 | |
| SCHEMBL1461837 | 0.65 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL12194126 | 0.64 | ALOX12 (0.45) | BRD4 | |
| SCHEMBL11135728 | 0.64 | SCN9A (0.49) | ALDH1A1ALDH1A3DRD2DRD4DRD3 | |
| SCHEMBL9032031 | 0.64 | SIGMAR1 (0.48) | ALDH1A1LMNAALDH3A1CMA1 | |
| Hydrochloric Acid SCHEMBL29906145 | 0.63 | GSK3A (0.37) | ALDH1A1LMNADHFRSMN1; SMN2GSK3A | |
| SCHEMBL30676985 | 0.63 | PTGER4 (0.55) | ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL689732 | 0.63 | PTGER4 (0.55) | ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL8126677 | 0.63 | POLB (0.58) | ALDH1A1SMN1; SMN2DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591255-B1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5478822-A | Tetrahydrobenzazepine derivatives which inhibit lipoxygenase | PFIZER INC. (US) | 1995-12-26 | — | — | US | disclosed |
| EP-0591255-A1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE. | PFIZER (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000335-A1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1993-01-07 | — | — | WO | disclosed |