Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031022 | 0.86 | ACHE (0.54) | ACHESIGMAR1OPRM1CHRM3 | |
| SCHEMBL27300983 | 0.75 | HTR2A (0.75) | ACHEHTR2ASIGMAR1OPRM1CCR3 | |
| SCHEMBL1519356 | 0.75 | HTR2A (0.75) | ACHEHTR2ASIGMAR1OPRM1CCR3 | |
| SCHEMBL8023030 | 0.75 | SIGMAR1 (0.75) | ACHEHTR2ASIGMAR1OPRM1DRD2 | |
| SCHEMBL27780881 | 0.75 | SIGMAR1 (0.55) | ACHEHTR2ASIGMAR1OPRM1CCR3 | |
| SCHEMBL4255182 | 0.74 | ACHE (0.71) | ACHEHTR2ASIGMAR1CCR3DRD2 | |
| SCHEMBL19658596 | 0.74 | OPRM1 (0.66) | ACHESIGMAR1OPRM1SLC22A1NR1I2 | |
| Hydrochloric Acid SCHEMBL1405913 | 0.74 | HTR2A (0.73) | ACHEHTR2ASIGMAR1OPRM1CCR3 | |
| SCHEMBL7276778 | 0.74 | SIGMAR1 (0.54) | ACHEHTR2ASIGMAR1OPRM1OPRD1 | |
| SCHEMBL27532290 | 0.73 | HTR2A (0.68) | ACHEHTR2ASIGMAR1OPRM1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699195-A1 | THIOINDOLE PYPERIDINYL DERIVATIVES USED AS ANTALGICS | LABORATOIRES UPSA (FR) | 1996-03-06 | — | — | EP | disclosed |
| US-5418242-A | Piperidinylthioindole derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as analgesics | LABORATOIRES UPSA (FR) | 1995-05-23 | — | — | US | disclosed |
| WO-1994026736-A1 | THIOINDOLE PYPERIDINYL DERIVATIVES USED AS ANTALGICS | LABORATOIRES UPSA (FR) | 1994-11-24 | — | — | WO | disclosed |
| US-5317025-A | Piperidinylthioindole derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as analgesics | LABORATOIRES USPA (FR) | 1994-05-31 | — | — | US | disclosed |