Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13533314 | 0.81 | HTR6 (0.63) | HTR6KDM4EALDH1A1HSD17B10HTR2C | |
| SCHEMBL8914068 | 0.77 | OPRM1 (0.65) | KDM4EDRD2ALOX15HTR1AHTR2A | |
| SCHEMBL3836149 | 0.74 | HTR6 (0.67) | HTR6KDM4EALDH1A1HSD17B10HTR2C | |
| SCHEMBL8916861 | 0.73 | NMT2 (0.48) | HTR6HTR2CHTR1DCYP1A2CYP3A4 | |
| SCHEMBL1675799 | 0.71 | HTR6 (0.67) | HTR6KDM4EALDH1A1HSD17B10HTR2C | |
| SCHEMBL2783986 | 0.71 | HTR6 (0.67) | HTR6KDM4EALDH1A1HSD17B10HTR2C | |
| SCHEMBL7460028 | 0.71 | HTR6 (0.67) | HTR6KDM4EALDH1A1HSD17B10HTR2C | |
| SCHEMBL2778860 | 0.71 | HTR6 (0.67) | HTR6KDM4EALDH1A1HSD17B10HTR2C | |
| SCHEMBL6631651 | 0.71 | KDM4E (0.70) | HTR6KDM4EALDH1A1HSD17B10HTR2C | |
| SCHEMBL8915519 | 0.71 | NMT2 (0.42) | HTR6HTR2CHTR1DCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |