Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 1/20 | 0.42 |
| ▸ | NMT1 | P30419 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 5/20 | 0.39 |
| ▸ | HTR1B | P28222 | 5/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916861 | 0.93 | NMT2 (0.48) | NMT2NMT1APPHTR2CADRB2 | |
| SCHEMBL8913781 | 0.82 | HTR1D (0.59) | APPHTR1DHTR1BHTR1ANOS3 | |
| SCHEMBL9033996 | 0.77 | IDO1 (0.36) | HTR1DHTR1BHTR1AIDO1 | |
| SCHEMBL27294918 | 0.76 | NMT2 (0.48) | NMT2NMT1APPHTR2CADRB2 | |
| SCHEMBL7665068 | 0.73 | HTR6 (0.54) | HTR2CHTR1DHTR1BHTR1AHTR6 | |
| SCHEMBL9033992 | 0.71 | HTR6 (0.53) | HTR2CHTR1DHTR1BHTR1ACYP1A2 | |
| SCHEMBL8913687 | 0.71 | HTR6 (0.54) | HTR2CHTR1DHTR1BHTR1AHTR6 | |
| SCHEMBL9040223 | 0.71 | SLC6A4 (0.32) | HTR1DHTR1BHTR6 | |
| SCHEMBL1445394 | 0.71 | GABRP (0.54) | APPHTR2CADRB2HTR1DHTR1B | |
| SCHEMBL31328282 | 0.71 | SLC6A4 (0.56) | APPHTR2CADRB2HTR1AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |