Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 15/20 | 0.62 |
| ▸ | DRD2 | P14416 | 14/20 | 0.62 |
| ▸ | HTR2A | P28223 | 5/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536094 | 0.80 | OPRM1 (0.78) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL14280720 | 0.79 | OPRM1 (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL9527241 | 0.78 | OPRM1 (0.78) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7543848 | 0.78 | HTR1A (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL9033992 | 0.77 | HTR6 (0.53) | HTR1ADRD2HTR2AKDM4EALOX15 | |
| SCHEMBL4194997 | 0.76 | HTR1A (1.00) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7859795 | 0.76 | OPRM1 (0.74) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL7649906 | 0.75 | HTR1A (0.83) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL1122147 | 0.74 | OPRM1 (0.71) | OPRM1OPRK1HTR1ADRD2HTR2A | |
| SCHEMBL13944353 | 0.73 | DRD2 (0.79) | OPRM1OPRK1HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |