Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033145 | 0.81 | POLB (0.54) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9032772 | 0.77 | ADORA3 (0.55) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9033367 | 0.75 | PYGM (0.52) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9033159 | 0.72 | ADORA3 (0.50) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL3905675 | 0.72 | ADORA3 (0.83) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL5363492 | 0.71 | TSHR (0.74) | ADORA3POLBLMNARECQLALDH1A1 | |
| SCHEMBL7920096 | 0.69 | ALDH1A1 (0.66) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL6951320 | 0.69 | ADORA3 (0.76) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9088494 | 0.69 | ADORA3 (0.76) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL20610477 | 0.69 | ADORA3 (1.00) | ADORA3POLBCACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474129-B1 | 1,4-Dihydropyridine derivatives and process for preparing the same | ACHIWA KAZUO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5336774-A | 1,4-dihydropyridine 3,5 carboxyl compounds | ACHIWA KAZUO (JP) | 1994-08-09 | — | — | US | disclosed |
| US-5234821-A | Process for preparing 1,4 dihydropyridine compounds | ACHIWA KAZUO (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0474129-A2 | 1,4-Dihydropyridine derivatives and process for preparing the same | Achiwa, Kazuo (JP) | 1992-03-11 | — | — | EP | disclosed |