Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 11/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035471 | 0.82 | SMN1; SMN2 (0.42) | MTNR1AMTNR1BHTR1ACYP1A2MAPT | |
| SCHEMBL24650780 | 0.82 | AADAT (0.42) | MTNR1AMTNR1BHTR1AHTR2ACYP1A2 | |
| SCHEMBL20478471 | 0.75 | CHRM2 (0.45) | HTR1AHTR2A | |
| SCHEMBL9372184 | 0.73 | HTR2A (0.42) | MTNR1AMTNR1BHTR1AHTR2ASMN1; SMN2 | |
| SCHEMBL20478601 | 0.72 | CA12 (0.46) | MTNR1AMTNR1BHTR1AHTR2ACYP1A2 | |
| SCHEMBL24651120 | 0.72 | HTR1A (0.42) | MTNR1AMTNR1BHTR1AHTR2A | |
| SCHEMBL24650766 | 0.71 | GLA (0.45) | CYP1A2MAPTCYP2C9 | |
| SCHEMBL9376505 | 0.70 | CYP19A1 (0.56) | MTNR1AMTNR1BHTR1ACYP1A2MAPT | |
| SCHEMBL24650905 | 0.70 | HTR1A (0.43) | MTNR1AMTNR1BHTR1AHTR2ACYP1A2 | |
| SCHEMBL24650923 | 0.70 | DRD2 (0.43) | MTNR1AMTNR1BHTR1AHTR2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | disclosed |
| US-5244888-A | Hexahydroindenopyrroles and hexahydrobenzisoindoles | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| US-5049564-A | Hypotensive, 5-hydroxytryptamine | ABBOTT LABORATORIES (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |