Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900041 | 0.88 | HTR1A (0.43) | HTR2AHTR1ACYP2D6MTNR1BMTNR1A | |
| SCHEMBL7935873 | 0.80 | MTNR1A (0.43) | HTR1ACYP2D6MTNR1BMTNR1AHCRTR1 | |
| SCHEMBL7926754 | 0.80 | HTR1A (0.55) | HTR2AHTR1AHCRTR1HCRTR2DRD2 | |
| SCHEMBL7238842 | 0.79 | ALDH1A1 (0.38) | — | |
| SCHEMBL7926523 | 0.78 | HTR1A (0.53) | HTR2AHTR1ADRD2 | |
| SCHEMBL7935755 | 0.76 | HTR1A (0.52) | HTR1AMTNR1BMTNR1AKDM4EHPGD | |
| SCHEMBL9052842 | 0.75 | DRD2 (0.45) | HTR1AHCRTR1HCRTR2DRD2 | |
| SCHEMBL9035210 | 0.73 | MTNR1A (0.41) | HTR2AHTR1AMTNR1BMTNR1ASMN1; SMN2 | |
| SCHEMBL9441175 | 0.72 | MTNR1B (0.44) | HTR2AHTR1AMTNR1BMTNR1ADRD2 | |
| SCHEMBL24650780 | 0.71 | AADAT (0.42) | HTR2AHTR1AMTNR1BMTNR1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586525-A1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES. | UPJOHN CO (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992020655-A1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-11-26 | — | — | WO | disclosed |