Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903542 | 0.91 | ALOX5 (0.48) | ALOX5MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL27255944 | 0.79 | ALOX5 (0.47) | ALOX5MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL22628563 | 0.76 | CTSV (0.49) | ALOX5MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL31053079 | 0.76 | CTSV (0.49) | ALOX5MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17452876 | 0.74 | ALDH1A1 (0.63) | ALOX5MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL903529 | 0.74 | AR (0.50) | ALOX5MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL29233384 | 0.73 | HSD17B10 (0.78) | ALOX5MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL10215057 | 0.71 | KIF11 (0.37) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2597652 | 0.71 | ALDH1A1 (1.00) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29391519 | 0.71 | ALDH1A1 (1.00) | MEN1KMT2AALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012040923-A1 | TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |