Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903534 | 0.91 | ALOX5 (0.53) | ALOX5MEN1KMT2AMAPTKDM4E | |
| SCHEMBL903532 | 0.80 | DAO (0.38) | KDM4EHSD17B10ALDH1A1TSHRHTR2A | |
| SCHEMBL903535 | 0.80 | MGLL (0.46) | ALOX5MEN1KMT2AMAPTHSD17B10 | |
| SCHEMBL903416 | 0.77 | HTR2A (0.45) | MEN1KMT2AKDM4EHTR2AHTR2C | |
| SCHEMBL6983296 | 0.74 | ALDH1A1 (0.78) | MEN1KMT2AMAPTKDM4EHSD17B10 | |
| SCHEMBL27255944 | 0.74 | ALOX5 (0.47) | ALOX5MEN1KMT2AMAPTKDM4E | |
| SCHEMBL903538 | 0.72 | FLT3 (0.58) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL17452876 | 0.70 | ALDH1A1 (0.63) | ALOX5MEN1KMT2AMAPTKDM4E | |
| SCHEMBL903529 | 0.69 | AR (0.50) | ALOX5MEN1KMT2AMAPTKDM4E | |
| SCHEMBL22628563 | 0.69 | CTSV (0.49) | ALOX5MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012040923-A1 | TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |