Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553384 | 0.77 | PRKCA (0.38) | PRKCAPOLBGAANPSR1ELANE | |
| SCHEMBL28019636 | 0.75 | PRKCA (0.43) | PRKCACYP4F2CYP4A11POLBGAA | |
| SCHEMBL9866275 | 0.73 | PRKCA (0.42) | PRKCACYP4F2CYP4A11POLBGAA | |
| SCHEMBL3517297 | 0.73 | PRKCA (0.42) | PRKCACYP4F2CYP4A11POLBGAA | |
| SCHEMBL7089654 | 0.73 | PRKCA (0.42) | PRKCACYP4F2CYP4A11POLBGAA | |
| SCHEMBL13647509 | 0.73 | MAPK1 (0.47) | PRKCACYP4F2CYP4A11POLBGAA | |
| SCHEMBL8816807 | 0.73 | PRKCA (0.42) | PRKCACYP4F2CYP4A11POLBGAA | |
| SCHEMBL6205519 | 0.71 | PRKCA (0.41) | PRKCACYP4F2CYP4A11POLBGAA | |
| SCHEMBL7222887 | 0.71 | PRKCA (0.41) | PRKCACYP4F2CYP4A11POLBGAA | |
| SCHEMBL9871939 | 0.71 | PRKCA (0.41) | PRKCACYP4F2CYP4A11POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294934-B1 | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids | PFIZER (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5319103-A | Intermediate diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-carboxylic acids | PFIZER INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0223397-B1 | PROCESS FOR 2-(1-OXO-3-THIOLANYL)-2-PENEM ANTIBIOTICS | PFIZER INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-5013729-A | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids | PFIZER INC. (US) | 1991-05-07 | — | — | US | disclosed |
| EP-0294934-A2 | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids | PFIZER INC. (US) | 1988-12-14 | — | — | EP | disclosed |
| WO-1988008845-A1 | DIASTEREOMERIC 5R,6S-6-(1R-HYDROXYETHYL)-2-(CIS-1-OXO-3-THIOLANYLTHIO)-2-PENEM-3-CARBOXYLIC ACIDS | PFIZER INC. (US) | 1988-11-17 | — | — | WO | disclosed |
| US-4739047-A | Intermediates for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics | PFIZER INC. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0223397-A2 | Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics | PFIZER INC. (US) | 1987-05-27 | — | — | EP | disclosed |