Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035190 | 0.80 | PARP1 (0.41) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL9034379 | 0.76 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL9035248 | 0.68 | LMNA (0.33) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL6139581 | 0.67 | PARP1 (0.32) | SMN1; SMN2KMT2AMEN1KDM4EPOLB | |
| SCHEMBL9035561 | 0.67 | PARP14 (0.36) | SMN1; SMN2LMNA | |
| SCHEMBL9035198 | 0.66 | PARP1 (0.33) | — | |
| SCHEMBL6139222 | 0.63 | PARP1 (0.44) | KMT2AMEN1KDM4EPOLBLMNA | |
| SCHEMBL9035008 | 0.63 | KDM4E (0.35) | ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL9035014 | 0.63 | KDM4E (0.35) | ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL7162615 | 0.62 | PARP1 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405442-B1 | 4,5-Dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid derivatives | MOCHIDA PHARM CO LTD (JP) | 1996-09-04 | — | — | EP | disclosed |
| US-5151431-A | Diuretics | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1992-09-29 | — | — | US | disclosed |
| EP-0405442-A1 | 4,5-Dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-02 | — | — | EP | disclosed |