Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.80 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.80 |
| ▸ | HTR1A | P08908 | 4/20 | 0.66 |
| ▸ | DRD2 | P14416 | 4/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5442134 | 0.89 | ADRA1D (1.00) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9698421 | 0.83 | ADRA1D (0.56) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL7778600 | 0.81 | ADRA1A (0.66) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL27483382 | 0.80 | ADRA1A (0.73) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL6526368 | 0.80 | DRD2 (0.85) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL10747609 | 0.80 | ADRA1D (0.72) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL6070108 | 0.79 | DRD2 (0.51) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL6070259 | 0.79 | DRD2 (0.51) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL8648856 | 0.79 | ADRA1D (0.64) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL3261221 | 0.79 | DRD2 (1.00) | ADRA1AADRA1DADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0502169-B1 | PIPERAZINE DERIVATIVES | WYETH JOHN & BROTHER LTD (GB) | 1996-01-03 | — | — | EP | disclosed |
| US-5346896-A | 1-(aryl or heteroaryl)-4[ω-(aryl or heteroaryl)ω-(aryl or heteroaryl)alkylene]piperazines | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-09-13 | — | — | US | disclosed |
| EP-0502169-A1 | PIPERAZINE DERIVATIVES. | WYETH JOHN & BROTHER LTD (GB) | 1992-09-09 | — | — | EP | disclosed |
| WO-1992006082-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |