Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
| ▸ | TRPV5 | Q9NQA5 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304581 | 0.85 | CCR1 (0.48) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL653874 | 0.79 | DRD2 (0.59) | OPRL1OPRM1OPRD1OPRK1HTR2C | |
| Hydrochloric Acid SCHEMBL23578391 | 0.78 | DRD2 (0.58) | OPRL1OPRM1OPRD1OPRK1HTR2C | |
| SCHEMBL7308048 | 0.77 | HTR1D (0.62) | OPRL1OPRM1TRPV6TRPV5 | |
| SCHEMBL9036686 | 0.76 | TRPV6 (0.59) | OPRL1OPRM1OPRD1TRPV6TRPV5 | |
| SCHEMBL7310103 | 0.76 | OPRL1 (0.61) | OPRL1OPRM1TRPV6TRPV5 | |
| SCHEMBL11799532 | 0.75 | OPRL1 (0.48) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL20455693 | 0.74 | OPRL1 (0.48) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL18282707 | 0.74 | OPRL1 (0.55) | OPRL1OPRM1OPRD1OPRK1TRPV6 | |
| SCHEMBL7040978 | 0.74 | OPRL1 (0.52) | OPRL1OPRM1TRPV6TRPV5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546583-B1 | Piperazinyl-and piperidinyl-cyclohexanols | BRISTOL MYERS SQUIBB CO (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5478828-A | Anxiolytic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5387593-A | Anxiolytic agents | BRISTON-MYERS SQUIBB (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0546583-A1 | Piperazinyl-and piperidinyl-cyclohexanols | Bristol-Myers Squibb Company (US) | 1993-06-16 | — | — | EP | disclosed |