Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462885 | 0.79 | CA1 (0.57) | MAOAMAOBCA1SMN1; SMN2KDM4E | |
| SCHEMBL3334799 | 0.76 | MEN1 (0.43) | MAOAMAOBPRCPPTGS2CA1 | |
| SCHEMBL6268223 | 0.74 | MAOA (0.57) | MAOAMAOBPRCPPTGS2CA1 | |
| SCHEMBL18562449 | 0.74 | CTH (0.43) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL23146476 | 0.73 | CA1 (0.38) | MAOAMAOBCA1SMN1; SMN2KDM4E | |
| SCHEMBL13330945 | 0.72 | ALDH1A1 (0.37) | MAOAPTGS2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL18255151 | 0.72 | MAOA (0.42) | MAOAMAOBPRCPPTGS2CA1 | |
| SCHEMBL15273122 | 0.71 | MAOA (0.41) | MAOAMAOBPRCPPTGS2CA1 | |
| SCHEMBL9072251 | 0.70 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EMAPTMAPK1GAA | |
| SCHEMBL6977486 | 0.70 | TAAR1 (0.41) | MAOAMAOBPRCPPTGS2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230120185-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-04-20 | — | — | US | disclosed |
| US-11485710-B2 | Heterocyclic amides as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-11-01 | — | — | US | disclosed |
| US-11485710-B2 | Heterocyclic amides as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-11-01 | — | — | US | disclosed |
| US-20210253532-A1 | Heterocyclic Amides as Kinase Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-08-19 | — | — | US | disclosed |
| US-20210253532-A1 | Heterocyclic Amides as Kinase Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-08-19 | — | — | US | disclosed |
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| US-10899716-B2 | Heterocyclic amides as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-01-26 | — | — | US | disclosed |
| EP-3298002-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-12-16 | — | — | EP | disclosed |
| EP-3298002-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-12-16 | — | — | EP | disclosed |
| CN-107624111-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-107624111-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-01-23 | — | — | CN | disclosed |
| WO-2016185423-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-11-24 | — | — | WO | disclosed |
| EP-0596109-B1 | SULFAMIDOSULFONAMIDE DERIVATIVES AND HERBICIDES | NISSAN CHEMICAL IND LTD (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5354731-A | Pyridinesulfonamide derivatives as herbicides | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1994-10-11 | — | — | US | disclosed |
| EP-0596109-A1 | SULFAMIDOSULFONAMIDE DERIVATIVES AND HERBICIDES. | NISSAN CHEMICAL IND LTD (JP) | 1994-05-11 | — | — | EP | disclosed |
| US-5152824-A | Selective for crop usage | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| US-5116405-A | Herbicides for crops | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| WO-1991013884-A2 | SULFAMIDOSULFONAMIDE DERIVATIVES AND HERBICIDES | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-09-19 | — | — | WO | disclosed |
| EP-0427174-A1 | Pyridinesulfonamide derivatives and herbicides | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-05-15 | — | — | EP | disclosed |
| US-4193905-A | Curable epoxide resin mixtures containing diaminopropanes | CIBA-GEIGY CORPORATION (US) | 1980-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253532-A1 | Heterocyclic Amides as Kinase Inhibitors | MAP3K19, MAP3K20, MAP3K1 | MAOA 1520/4885MAOB 1362/4885PRCP 4411/4885 |
| US-20230120185-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | MAP3K19, MAP3K20, MAP3K1 | MAOA 1520/4885MAOB 1362/4885PRCP 4411/4885 |
| US-11485710-B2 | Heterocyclic amides as kinase inhibitors | MAP3K19, MAP3K20, MAP3K1 | MAOA 1520/4885MAOB 1362/4885PRCP 4411/4885 |
| US-10899716-B2 | Heterocyclic amides as kinase inhibitors | MAP3K19, MAP3K20, MAP3K1 | MAOA 1520/4885MAOB 1362/4885PRCP 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.