Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27394377 | 0.82 | ADRA1A (0.55) | CHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL27469141 | 0.77 | ACHE (0.40) | CHRM2CHRM1CHRM3DRD2DRD3 | |
| SCHEMBL7606129 | 0.77 | DRD2 (0.57) | CHRM2CHRM1CHRM3DRD2DRD3 | |
| SCHEMBL17682886 | 0.75 | HTR1A (0.51) | CHRM2CHRM1CHRM3DRD2DRD3 | |
| SCHEMBL27390763 | 0.74 | ALDH1A1 (0.49) | — | |
| SCHEMBL24029258 | 0.74 | DRD2 (0.54) | CHRM2CHRM1CHRM3DRD2DRD3 | |
| SCHEMBL31324598 | 0.74 | DRD2 (0.73) | CHRM2CHRM1CHRM3DRD2DRD3 | |
| SCHEMBL14545524 | 0.74 | DRD2 (0.54) | CHRM2CHRM1CHRM3DRD2DRD3 | |
| SCHEMBL16482975 | 0.74 | DRD2 (0.54) | CHRM2CHRM1CHRM3DRD2DRD3 | |
| SCHEMBL23856659 | 0.74 | HTR1A (0.38) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | disclosed |
| US-5244888-A | Hexahydroindenopyrroles and hexahydrobenzisoindoles | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| US-5049564-A | Hypotensive, 5-hydroxytryptamine | ABBOTT LABORATORIES (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |