Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | P4HA1 | P13674 | 3/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ASPH | Q12797 | 2/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764581 | 0.83 | HCAR2 (0.41) | HCAR2MGAMP4HA1P4HTMKDM4E | |
| SCHEMBL19857480 | 0.81 | GABRP (0.46) | HCAR2MGAMP4HA1P4HTMKDM4E | |
| SCHEMBL30615442 | 0.80 | DHODH (0.42) | HCAR2KDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL21464267 | 0.80 | DHODH (0.42) | HCAR2KDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL29819483 | 0.79 | TSHR (0.44) | MGAMP4HA1P4HTMKDM4EMIF | |
| SCHEMBL10447248 | 0.79 | MGAM (0.38) | HCAR2MGAMP4HA1P4HTMKDM4E | |
| SCHEMBL10768873 | 0.75 | MGAM (0.35) | HCAR2MGAMP4HA1P4HTMKDM4E | |
| SCHEMBL10768907 | 0.75 | MGAM (0.38) | MGAMP4HA1P4HTMKDM4EMIF | |
| SCHEMBL10768874 | 0.74 | MGAM (0.37) | MGAMP4HA1P4HTMKDM4EALDH1A1 | |
| SCHEMBL10515854 | 0.73 | ASPH (0.50) | MGAMKDM4EASPHKDM8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741705-A1 | 4-(2-(3-ARYLOXY-2-HYDROXYPROPYLAMINO ALKYLOXY)-5-NITROPHENYL)-1,4-DIHYDROPYRIDINES AS ANTIHYPERTENSIVE AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-13 | — | — | EP | disclosed |