Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | EEF2K | O00418 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038562 | 0.83 | ADORA2A (0.43) | ADORA2BADORA2AMAPK1PDE4APDE4B | |
| SCHEMBL9037741 | 0.80 | ADORA2B (0.40) | ADORA2BADORA2AMAPK1PDE4APDE4B | |
| SCHEMBL9049648 | 0.80 | ADORA2A (0.40) | ADORA2BADORA2AMAPK1PDE4APDE4B | |
| SCHEMBL9038343 | 0.78 | ADORA2A (0.39) | ADORA2BADORA2AKMT2AMAPK1PDE4A | |
| SCHEMBL9038676 | 0.77 | TAS2R14 (0.48) | TP53POLBMEN1KMT2ARXFP1 | |
| SCHEMBL9039738 | 0.76 | ADORA2B (0.40) | ADORA2BADORA2AEEF2KMETAP2TP53 | |
| SCHEMBL9037887 | 0.76 | PDE4B (0.45) | ADORA2BKMT2AMAPK1PDE4BTSHR | |
| SCHEMBL9038196 | 0.75 | ADORA2A (0.45) | ADORA2BADORA2AMAPK1PDE4APDE4B | |
| SCHEMBL9039306 | 0.70 | PDE4B (0.43) | ADORA2BADORA2AMAPK1PDE4APDE4B | |
| SCHEMBL9038040 | 0.70 | PDE4B (0.43) | ADORA2BADORA2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696590-A1 | Pyrido[2,3-d]pyrimidine derivatives, their preparation and their use as anti-asthma agents | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |