Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039306 | 0.90 | PDE4B (0.43) | ADORA2BADORA2ACDK4CCND1CCND2 | |
| SCHEMBL9038040 | 0.90 | PDE4B (0.43) | ADORA2BADORA2ACDK4CCND1CCND2 | |
| SCHEMBL9039080 | 0.88 | ADORA2A (0.46) | ADORA2BADORA2AADORA1ADORA3PDE5A | |
| SCHEMBL9038562 | 0.85 | ADORA2A (0.43) | ADORA2BADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL9049648 | 0.81 | ADORA2A (0.40) | ADORA2BADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL9037775 | 0.80 | ADORA2B (0.40) | ADORA2BADORA2ATSHRMAPK1PDE4B | |
| SCHEMBL9038343 | 0.79 | ADORA2A (0.39) | ADORA2BADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL9038556 | 0.79 | PDE4B (0.44) | ADORA2BADORA2ACDK4CCND1CCND2 | |
| SCHEMBL9039588 | 0.78 | SIRT1 (0.39) | ADORA2BADORA2ACDK4CCND1CCND2 | |
| SCHEMBL9038552 | 0.77 | PDE4B (0.45) | ADORA2BADORA2ACDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696590-A1 | Pyrido[2,3-d]pyrimidine derivatives, their preparation and their use as anti-asthma agents | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |