Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039917 | 0.80 | ADORA2B (0.40) | ADORA2BADORA2AALDH1A1EEF2KPDE4A | |
| SCHEMBL9038401 | 0.80 | ADORA2B (0.40) | ADORA2BADORA2AALDH1A1PDE4APDE4B | |
| SCHEMBL9037775 | 0.76 | ADORA2B (0.40) | ADORA2BADORA2AEEF2KPDE4APDE4B | |
| SCHEMBL9018998 | 0.76 | ADORA2B (0.48) | ADORA2BADORA2AALDH1A1EEF2KPDE4A | |
| SCHEMBL9019089 | 0.76 | ADORA2B (0.44) | ADORA2BADORA2AALDH1A1EEF2KPDE4A | |
| SCHEMBL9039673 | 0.70 | ADORA2A (0.47) | ADORA2BADORA2AALDH1A1EEF2KPDE4A | |
| SCHEMBL9038258 | 0.69 | EEF2K (0.46) | ADORA2BADORA2AALDH1A1EEF2KPDE4A | |
| SCHEMBL9039634 | 0.68 | KDM4E (0.49) | ALDH1A1EEF2KLMNATP53POLB | |
| SCHEMBL9038294 | 0.68 | ADORA2B (0.40) | ADORA2BADORA2AALDH1A1PDE4APDE4B | |
| SCHEMBL28144480 | 0.68 | EEF2K (0.38) | ADORA2BADORA2AALDH1A1EEF2KPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696590-A1 | Pyrido[2,3-d]pyrimidine derivatives, their preparation and their use as anti-asthma agents | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |