SCHEMBL9038110

SCHEMBL9038110

COc1cccc2c1CC=C[CH]2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA4 P22748 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
ACHE P22303 1/20 0.39
DRD2 P14416 4/20 0.37
DRD3 P35462 4/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
CYP3A4 P08684 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
ALOX12 P18054 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8766176 0.82 SLC6A2 (0.43) CA12CA1CA2CA4CA7
SCHEMBL5060888 0.81 ALDH1A1 (0.40) KDM4EALDH1A1MAPTHPGDMAPK1
SCHEMBL4308679 0.76 KDM4E (0.42) CA1CA2CA4ACHEKDM4E
SCHEMBL9304448 0.72 BCL2L1 (0.36) CA1CA2DRD2DRD3ALDH1A1
SCHEMBL506157 0.72 DRD2 (0.46) CA12CA1CA2CA4CA7
SCHEMBL3625139 0.72 ADRA1A (0.41) CA12CA1CA2CA4CA7
SCHEMBL10817023 0.72 CYP2D6 (0.36) ALDH1A1LMNACYP3A4NOTUM
SCHEMBL15351296 0.72 TRPA1 (0.34) ALDH1A1
SCHEMBL7544325 0.69 ADRA1A (0.50) CA12CA1CA2CA4CA7
SCHEMBL30485650 0.69 DRD2 (0.40) CA12CA1CA2CA4CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0716654-A1 SUBSTITUTED LACTIC-ACID DERIVATIVES WITH AN ORGANIC N-GROUP IN THE BETA POSITION, THEIR PREPARATION AND THEIR USE AS HERBICIDES AND ANTIDOTES BASF AKTIENGESELLSCHAFT (DE) 1996-06-19 EP disclosed
EP-0695295-A1 3-(HETERO)ARYL CARBOXYLIC ACID DERIVATIVES, METHODS OF PREPARING THEM AND INTERMEDIATES USED IN THEIR PREPARATION BASF AKTIENGESELLSCHAFT (DE) 1996-02-07 EP disclosed
EP-0125756-A2 Fused imidazole compounds, processes for the preparation thereof and pharmaceutical compositions containing them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1984-11-21 EP disclosed