SCHEMBL903918 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	WNT3A	P56704	13/20	0.40

▸	ABL1	P00519	1/20	0.37

▸	HDAC4	P56524	2/20	0.36

▸	MEN1	O00255	1/20	0.34

▸	NPC1	O15118	1/20	0.34

▸	RAB9A	P51151	1/20	0.34

▸	KMT2A	Q03164	1/20	0.34

▸	HCAR2	Q8TDS4	1/20	0.34

▸	BRAF	P15056	1/20	0.33

▸	PSEN1	P49768	1/20	0.33

▸	PSEN2	P49810	1/20	0.33

▸	APH1B	Q8WW43	1/20	0.33

▸	NCSTN	Q92542	1/20	0.33

▸	APH1A	Q96BI3	1/20	0.33

▸	PSENEN	Q9NZ42	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3098901	0.83	MEN1 (0.44)	MEN1NPC1RAB9AKMT2A
SCHEMBL30619390	0.83	MEN1 (0.44)	MEN1NPC1RAB9AKMT2A
SCHEMBL20743619	0.78	LOXL2 (0.43)	WNT3AABL1HDAC4HCAR2
SCHEMBL21411855	0.77	ESR1 (0.52)	WNT3AABL1HDAC4MEN1NPC1
SCHEMBL26818530	0.74	HPGDS (0.48)	WNT3AABL1HDAC4NPC1RAB9A
SCHEMBL1585520	0.73	NPC1 (0.50)	MEN1NPC1RAB9AKMT2A
SCHEMBL17795051	0.71	EGLN1 (0.44)	MEN1NPC1RAB9AKMT2A
SCHEMBL19461191	0.71	ALDH1A1 (0.56)	MEN1NPC1RAB9AKMT2A
SCHEMBL2325516	0.71	LTA4H (0.47)	MEN1NPC1RAB9AKMT2A
SCHEMBL13750511	0.71	WNT3A (0.38)	WNT3AABL1HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012041158-A1	TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF	上海恒瑞医药有限公司 (CN)	2012-04-05	—	—	WO	disclosed