Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.57 |
| ▸ | PDE6D | O43924 | 4/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041371 | 0.90 | PDE6D (0.54) | DRD2DRD3PDE6DHTTKDM4E | |
| SCHEMBL9040832 | 0.90 | DRD2 (0.60) | DRD2DRD3PDE6DAGTR2HTT | |
| SCHEMBL9042322 | 0.90 | KDM4E (0.66) | DRD2PDE6DHTTKDM4ELMNA | |
| SCHEMBL9043441 | 0.89 | TP53 (0.56) | DRD2PDE6DAGTR2HTTKDM4E | |
| SCHEMBL9041081 | 0.88 | ALDH1A1 (0.51) | DRD2DRD3PDE6DAGTR2HTT | |
| SCHEMBL8397011 | 0.87 | DRD2 (0.58) | DRD2DRD3PDE6DAGTR2HTT | |
| SCHEMBL9041236 | 0.84 | AGTR1 (0.66) | AGTR2AGTR1PPARG | |
| SCHEMBL9040419 | 0.84 | HDAC1 (0.52) | DRD2AGTR2HTTAGTR1TBXA2R | |
| SCHEMBL9043424 | 0.83 | GRM2 (0.53) | DRD2PDE6DHTTKDM4ELMNA | |
| SCHEMBL9043483 | 0.83 | PPARG (0.67) | AGTR2AGTR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |