Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP10 | P09238 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | GALR3 | O60755 | 2/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.47 |
| ▸ | PTAFR | P25105 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042213 | 0.91 | PPARG (0.47) | MMP3MMP7MMP10MMP8MMP12 | |
| SCHEMBL9043441 | 0.90 | TP53 (0.56) | AGTR2PPARGHRH3DRD2TBXA2R | |
| SCHEMBL9039784 | 0.90 | PPARG (0.46) | MMP3MMP7MMP10MMP8MMP12 | |
| SCHEMBL9041469 | 0.89 | PPARG (0.52) | RAB9AAGTR1AGTR2PPARGTBXA2R | |
| SCHEMBL9041081 | 0.88 | ALDH1A1 (0.51) | AGTR2PPARGDRD2TBXA2RHTT | |
| SCHEMBL9043352 | 0.88 | RAB9A (0.55) | RAB9AEDNRAAGTR1AGTR2PPARG | |
| SCHEMBL9040689 | 0.87 | TNF (0.59) | HDAC1HDAC6TNFGALR3NR2F2 | |
| SCHEMBL9040518 | 0.87 | MMP7 (0.53) | HDAC1HDAC6MMP7MMP8MMP12 | |
| SCHEMBL9042214 | 0.87 | HDAC1 (0.54) | HDAC1HDAC6MMP3MMP7MMP10 | |
| SCHEMBL9042322 | 0.87 | KDM4E (0.66) | RAB9ADRD2TBXA2RMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |