Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755659 | 0.87 | NQO2 (0.46) | NQO2POLBSUCNR1KDM4ECKS1B | |
| SCHEMBL903992 | 0.87 | NQO2 (0.46) | NQO2POLBSUCNR1KDM4ECKS1B | |
| SCHEMBL21583862 | 0.80 | POLB (0.46) | NQO2POLBKDM4ECKS1BSKP1 | |
| SCHEMBL21089804 | 0.80 | NQO2 (0.49) | NQO2POLBKDM4ENAMPTCTSK | |
| SCHEMBL12651361 | 0.78 | FAAH (0.52) | NQO2POLBKDM4ENAMPTCTSK | |
| SCHEMBL5729170 | 0.77 | CTSS (0.54) | NQO2POLBKDM4ENAMPTCTSK | |
| SCHEMBL18070221 | 0.77 | CTSK (0.47) | NQO2POLBKDM4ENAMPTCTSK | |
| SCHEMBL15125652 | 0.77 | NPC1 (0.49) | NQO2POLBKDM4ENAMPTCTSK | |
| SCHEMBL9985225 | 0.76 | NQO2 (0.52) | NQO2POLBKDM4ECYP3A4NAMPT | |
| SCHEMBL16787407 | 0.76 | POLB (0.62) | NQO2POLBKDM4ENAMPTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |