Sugi Predict

Sugi Predict / Compounds / SCHEMBL904476

SCHEMBL904476

SCHEMBL904476

O=C(O)C[C@@H](O)c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ GABBR2 O75899 1/20 0.55
▸ GABBR1 Q9UBS5 1/20 0.55
▸ LMNA P02545 3/20 0.54
▸ KDM4E B2RXH2 2/20 0.52
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ BCAT2 O15382 1/20 0.52
▸ NPC1 O15118 1/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ MAPK1 P28482 1/20 0.50
▸ CYP2C19 P33261 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ AOC3 Q16853 3/20 0.48
▸ CYP2D6 P10635 1/20 0.46
▸ SRC P12931 1/20 0.46
▸ TAAR1 Q96RJ0 1/20 0.46
▸ CPA1 P15085 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL904490 1.00 GABBR2 (0.55) GABBR2GABBR1LMNAKDM4EL3MBTL1
SCHEMBL186610 1.00 GABBR2 (0.55) GABBR2GABBR1LMNAKDM4EL3MBTL1
Hydrochloric Acid SCHEMBL1374836 0.98 GABBR2 (0.53) GABBR2GABBR1LMNAKDM4EL3MBTL1
Hydrochloric Acid SCHEMBL1373206 0.98 GABBR2 (0.53) GABBR2GABBR1LMNAKDM4EL3MBTL1
Ammonia Solution, Strong SCHEMBL2341560 0.98 GABBR2 (0.53) GABBR2GABBR1LMNAKDM4EL3MBTL1
Thiophene SCHEMBL27621795 0.88 GABBR2 (0.46) GABBR2GABBR1LMNAKDM4EL3MBTL1
SCHEMBL27694460 0.87 FFAR1 (0.57) GABBR2GABBR1LMNA
SCHEMBL9061130 0.86 LMNA (0.54) GABBR2GABBR1LMNAKDM4EL3MBTL1
SCHEMBL28580617 0.83 GABBR2 (0.48) GABBR2GABBR1LMNAKDM4EL3MBTL1
SCHEMBL5384514 0.83 KDM4E (0.50) GABBR2GABBR1LMNAKDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109232220-B Chemical resolution method of 3-hydroxy-3-phenylpropionic acid compound 上海健康医学院 2021-09-10 — — CN claimed
CN-108998430-B Interface self-assembly carbonyl reductase and application thereof in synthesis of (R) -3-hydroxy-3-ethyl phenylpropionate 浙江工业大学 2020-11-13 — — CN claimed
CN-108998430-A A kind of interface self assembly carbonyl reductase and the application in the synthesis of (R) -3- hydroxyl -3- phenylpropionate 浙江工业大学 2018-12-14 — — CN claimed
US-20260042759-A1 INHIBITOR CONTAINING BICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI HANSOH BIOMEDICAL CO LTD (CN) 2026-02-12 — — US disclosed
US-12466823-B2 Inhibitor containing bicyclic derivative, preparation method therefor and use thereof SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) 2025-11-11 — — US disclosed
EP-3971187-B1 INHIBITOR CONTAINING BICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI HANSOH BIOMEDICAL CO LTD (CN) 2025-05-07 — — EP disclosed
CN-118108598-A Method for synthesizing chiral beta-hydroxy carboxylic ester by catalysis of ruthenium complex 中国科学院大连化学物理研究所 2024-05-31 — — CN disclosed
US-20230339934-A1 PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS RAQUALIA PHARMA INC. (JP) 2023-10-26 — — US disclosed
US-20230339934-A1 PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS RAQUALIA PHARMA INC. (JP) 2023-10-26 — — US disclosed
CN-116444515-A Di-ring derivative-containing inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2023-07-18 — — CN disclosed
CN-115974897-A Bicyclic derivative-containing inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2023-04-18 — — CN disclosed
EP-0770085-B1 HETEROAROMATIC DIPHOSPHINES AS CHIRAL LIGANDS CHEMI SPA (IT) 1999-09-22 — — EP disclosed
US-5907045-A Heteroaromatic diphosphines as chiral ligands ITALFARMACO SUD S.P.A. (IT) 1999-05-25 — — US disclosed
EP-0770085-A1 HETEROAROMATIC DIPHOSPHINES AS CHIRAL LIGANDS ITALFARMACO SUD S.p.A. (IT) 1997-05-02 — — EP disclosed
WO-1996001831-A1 HETEROAROMATIC DIPHOSPHINES AS CHIRAL LIGANDS ITALFARMACO SUD S.P.A. (IT) 1996-01-25 — — WO disclosed
WO-1995018781-A1 METHODS FOR SYNTHESIZING OLIGOMERS CONTAINING HYDROXY ACID UNITS METABOLIX, INC. (US) 1995-07-13 — — WO disclosed
EP-0494203-B1 SYNTHESIS OF ARYL ALKANEDIOLS HAVING HIGH OPTICAL PURITY EASTMAN KODAK CO (US) 1993-12-08 — — EP disclosed
EP-0494203-A1 SYNTHESIS OF ARYL ALKANEDIOLS HAVING HIGH OPTICAL PURITY. EASTMAN KODAK CO (US) 1992-07-15 — — EP disclosed
WO-1991004334-A1 SYNTHESIS OF ARYL ALKANEDIOLS HAVING HIGH OPTICAL PURITY EASTMAN KODAK COMPANY (US) 1991-04-04 — — WO disclosed
US-4921798-A Synthesis of (aryl or arylalkyl)-3-hydroxy propionic acids and aryl alkanediols having high optical purity EASTMAN KODAK COMPANY (US) 1990-05-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260042759-A1 INHIBITOR CONTAINING BICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF FAR1, CYP4A11, CYP11B1 GABBR2 1787/4885GABBR1 2094/4885LMNA 1284/4885
US-12466823-B2 Inhibitor containing bicyclic derivative, preparation method therefor and use thereof RET, REL, GOT1 GABBR2 2967/4885GABBR1 3066/4885LMNA 2339/4885
US-20230339934-A1 PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS TRPV4, TRPV1, TRPV2 GABBR2 979/4885GABBR1 850/4885LMNA 4199/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.