Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.62 |
| ▸ | CES1 | P23141 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | PTPRC | P08575 | 4/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.59 |
| ▸ | PTPRF | P10586 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043540 | 0.91 | PTPRC (0.69) | MAPTPTPRCPTPN1PTPN2PTPRF | |
| SCHEMBL9042648 | 0.89 | PTPRC (0.59) | CES2CES1MAPTPTPRCPTPN1 | |
| SCHEMBL9043116 | 0.89 | KDM4E (0.57) | CES2CES1MAPTPTPRCPTPN1 | |
| SCHEMBL906482 | 0.89 | CES2 (0.78) | CES2CES1MAPTPTPRCPTPN1 | |
| SCHEMBL9044645 | 0.86 | L3MBTL1 (0.61) | CES2CES1MAPTPTPRCPTPN1 | |
| SCHEMBL9044396 | 0.85 | PKM (0.72) | MAPTPTPRCPTPN1PTPN2PTPRF | |
| SCHEMBL9043716 | 0.84 | MAPT (0.56) | MAPTPTPRCPTPN1PTPN2PTPRF | |
| SCHEMBL9042386 | 0.84 | MAPT (0.61) | CES2CES1MAPTRAB9ACA1 | |
| SCHEMBL16917421 | 0.84 | TP53 (0.67) | PTPRCPTPN1PTPN2PTPRFL3MBTL1 | |
| SCHEMBL9042263 | 0.83 | MAPT (0.56) | MAPTPTPRCPTPN1PTPN2PTPRF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |