Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazole SCHEMBL8992494 | 0.92 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9255026 | 0.84 | AGTR1 (0.50) | AGTR1AGTR2ACHE | |
| Hydrochloric Acid SCHEMBL8992382 | 0.84 | AGTR1 (0.56) | AGTR1AGTR2ACHE | |
| SCHEMBL9024785 | 0.82 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL9044274 | 0.81 | AGT (0.51) | AGTR1AGTR2 | |
| SCHEMBL9045991 | 0.79 | ACHE (0.50) | ACHE | |
| SCHEMBL7435257 | 0.79 | ACHE (0.54) | AGTR1AGTR2ACHE | |
| SCHEMBL9025617 | 0.77 | AGTR1 (0.59) | AGTR1AGTR2 | |
| SCHEMBL8992458 | 0.77 | MEN1 (0.42) | — | |
| SCHEMBL9043006 | 0.76 | ACHE (0.49) | AGTR1AGTR2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531876-B1 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5424316-A | Imidazopyridine derivatives for the treatment of hypertension | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| US-5409936-A | Useful in prophylaxix; exhibits potent angiotensin ii inhibitory acivities | TANABE SEIYAKU CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| US-5268377-A | Imidazoindolizine derivatives process for preparation thereof and use thereof to treat hypertension | TANABE SEIYAKU CO., LTD. (JP) | 1993-12-07 | — | — | US | disclosed |
| CN-1070913-A | Imidazo indolizine derivative and preparation method thereof | TANABE SEIYAKU CO (JP) | 1993-04-14 | — | — | CN | disclosed |
| EP-0531876-A2 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531874-A1 | Imidazopyridine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |